| Form |
White or almost white, crystalline powder or colourless crystals |
| MF |
C12H17N4OS.ClH.Cl |
| MW | 337.27 |
| Melting point |
250 °C (dec.)(lit.) |
| Fp | 9°C |
| Density |
1.3766 (rough estimate) |
| Refractive index | 1.6000 (estimate) |
| Pka | 4.8 (Uncertain);9.0 (Uncertain) |
| Storage temp. |
room temp |
|
ITEM |
STANDARD |
|
Appearance |
White or almost white, crystalline powder or colourless crystals |
|
Identification |
IR,Characteristic Reaction and Test of chlorides |
|
Assay |
98.5-101.0 |
|
pH |
2.7-3.3 |
|
Absorbance of solution |
=<0.025 |
|
Solubility |
Freely Soluble in Water,Soluble in Glycerol, Slightly Soluble in Alcohol |
|
Appearance of solution |
Clear and not more than Y7 |
|
Sulphates |
=<300PPM |
|
Limit of nitrate |
No brown ring is produced |
|
Heavy metals |
=<20 PPM |
|
Related substances |
Any impurity % =<0.4 |
|
Water |
=<5.0 |
|
Sulphated ash/Residueon ignition |
=<0.1 |
|
Chromatographic purity |
=<1.0 |
Thiamine is used in the biosynthesis of the neurotransmitter acetylcholine and gamma-aminobutyric acid (GABA). In yeast, TPP is also required in the first step of alcoholic fermentation.
Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.
